美國英語的一大特色就是詞首字母縮寫特別多。
 一般的美國聯邦政府部門縮寫有：
USDA - Department of Agriculture
DoC - Department of Commerce
DoI - Department of the Interior
DoL - Department of Labor
DoS - Department of State
DoT - Department of Transportation
DoJ - Department of Justice
ED - Department of Education
HHS - Department of Health and Human Services
DoE - Department of Energy
VA - Department of VeteransAffairs
HUD - Department of Housing and Urban Development
DHS - Department of Homeland Security
DEA - Drug Enforcement Administration
ICE - United States Immigration and Customs Enforcement
IRS - Internal Revenue Service
ATF - Bureau of Alcohol, Tobacco, Firearms & Explosives
NCIS - Naval Criminal Investigative Service
JAG - Judge Advocate General
(A)USA - (Assistant) United States Attornery
USCIS - United States Citizenship and Immigration Service
USPS - United States Postal Service
SEC - Security and Exchange Commission
FCC - Federal Communication Commission
FTC - Federal Trade Commission
FAA - Federal Aviation Administration
NTSB - National Transportation Safety Board
GSA - General Service Administration
DIA - Defense Intelligence Agency
NRO - National Reconnaissance Office
NGA - National Geospatial-Intelligence Agency
EPA - Environmental Protection Agency
FEC - Federal Election Commission
NASA - National Aeronautics and Space Administration
NSF - National Science Foundation
AMTRAK - National Railroad Passenger Corporation
SSA - Social Security Administration
NOAA - National Oceanic & Atmospheric Administration
USGS - United States Geological Survey
FEMA - Federal Emergency Management Agency
CBP - United States Customs and Border Protection
CDC - Centers for Disease Control and Prevention
FDA - Food and Drug Administration
NIH - National Institutes of Health
DARPA - Defense Advanced Research Projects Agency
FBI - Federal Bureau of Investigation, a bureau within the Department of Justice
CIA - Central Intelligence Agency, an independant government agency
NSA - National Security Agency, an intelligence/combat support agency within the Department of Defense
DoD - Department of Defense
USSS - United States Secret Service